Wolverines guard Brandon Rush scored a career-high 34 points, but his team failed to keep pace against No. 16 Michigan State on Friday.
Rush, who is ranked No. 19 in the country, had nine points, eight assists and six rebounds, and the Wolverines outscored the Spartans 17-8 over the final 10 minutes.
He scored eight points and added four rebounds in 17 minutes.
Michigan (18-2, 10-2 Big Ten) was also without forward Ben Bentil, who left the game with a lower back injury.
Sophomore guard Andrew Jones, who also missed Friday’s game with an illness, is expected to return next week.
The Spartans, who beat No. 8 Wisconsin 78-70 on Saturday, were playing their first game in 24 days since beating No. 4 Ohio State on Nov. 18.
Michigan has lost three straight games.
Michigan’s next game is scheduled for Saturday against No, 3 Kansas State.
Michigan State (16-3, 6-4 Big Ten), which was ranked No: 15 in the preseason AP Top 25 poll, has lost two of three and is now 2-8 in Big Ten play.
The Spartans are 5-4 against ranked teams and 1-5 against teams ranked in the top 10.
Michigan beat the Wildcats 83-78 on Saturday.